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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2B3
All Species:
12.42
Human Site:
S504
Identified Species:
30.37
UniProt:
Q9UQQ2
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UQQ2
NP_005466.1
575
63225
S504
G
L
P
H
L
S
S
S
G
C
P
R
G
L
S
Chimpanzee
Pan troglodytes
XP_001145612
575
63234
S504
G
L
P
H
L
S
S
S
G
C
P
R
G
L
S
Rhesus Macaque
Macaca mulatta
XP_001108790
570
62567
S499
G
L
P
H
L
S
S
S
G
C
P
R
G
L
S
Dog
Lupus familis
XP_546938
639
67478
A548
H
Y
F
S
S
L
G
A
A
A
W
P
P
A
S
Cat
Felis silvestris
Mouse
Mus musculus
O09039
548
60469
A476
G
C
P
P
S
H
G
A
E
A
L
P
G
Q
V
Rat
Rattus norvegicus
P50745
368
40414
A298
P
P
G
H
G
A
E
A
L
R
G
Q
V
T
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506291
650
72002
S573
G
L
P
H
L
S
P
S
G
C
P
R
M
H
I
Chicken
Gallus gallus
XP_001234467
640
70256
A569
Y
F
C
N
T
A
P
A
A
P
P
V
P
P
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001338493
596
67866
A525
I
P
L
E
C
G
A
A
C
D
V
M
L
A
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624395
579
64607
A509
A
N
H
A
I
R
S
A
H
H
N
V
S
G
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
96.5
34.2
N.A.
72.6
30.2
N.A.
63
33.1
N.A.
44.9
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
100
98.9
96.8
45
N.A.
78.9
38.4
N.A.
68.9
45.7
N.A.
55.8
N.A.
N.A.
46.4
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
20
6.6
N.A.
73.3
6.6
N.A.
0
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
26.6
26.6
N.A.
73.3
26.6
N.A.
20
N.A.
N.A.
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
10
0
20
10
60
20
20
0
0
0
20
0
% A
% Cys:
0
10
10
0
10
0
0
0
10
40
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% D
% Glu:
0
0
0
10
0
0
10
0
10
0
0
0
0
0
0
% E
% Phe:
0
10
10
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
50
0
10
0
10
10
20
0
40
0
10
0
40
10
0
% G
% His:
10
0
10
50
0
10
0
0
10
10
0
0
0
10
0
% H
% Ile:
10
0
0
0
10
0
0
0
0
0
0
0
0
0
20
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
40
10
0
40
10
0
0
10
0
10
0
10
30
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
10
0
0
% M
% Asn:
0
10
0
10
0
0
0
0
0
0
10
0
0
0
10
% N
% Pro:
10
20
50
10
0
0
20
0
0
10
50
20
20
10
20
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% Q
% Arg:
0
0
0
0
0
10
0
0
0
10
0
40
0
0
0
% R
% Ser:
0
0
0
10
20
40
40
40
0
0
0
0
10
0
40
% S
% Thr:
0
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
10
20
10
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
10
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _